Model

ESM-2

ESM-2 is a family of protein sequence encoders that produce representations for downstream protein analyses.

Sources (3)

facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json

3 evaluations · 11 metric rows

How it worksESM-2 workflow

Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation.

Sources (3)

Overview

Model type

Masked-token protein transformer encoder

Sources (3)

Inputs

Single amino-acid sequences.

Sources (3)

Outputs

Residue embeddings, sequence representations and masked-token predictions.

Sources (3)

Access

Official project documentation and implementation: https://github.com/facebookresearch/esm

Sources (3)

Source reviewed · Automated source review, 2026-09-16. All specifications and missing details

Evaluations and results

3 evaluations · 11 metric rows. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ESM2 8M	Protocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification) Dataset: human and viral proteins	92.15% Prec. percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · source checked Methods, coverage and source ESM2 8M: Held-out human-versus-virus protein classification Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1. Aggregation: Not reported Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 8M, column Prec.; XML row4 column4
Configuration: ESM2 8M	Protocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification) Dataset: human and viral proteins	92.33% Recall percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · source checked Methods, coverage and source ESM2 8M: Held-out human-versus-virus protein classification Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1. Aggregation: Not reported Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 8M, column Recall; XML row4 column5
Configuration: ESM2 8M	Protocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification) Dataset: human and viral proteins	98.09% AUROC percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · source checked Methods, coverage and source ESM2 8M: Held-out human-versus-virus protein classification Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1. Aggregation: Not reported Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 8M, column AUC (%); XML row4 column2
Configuration: ESM2 8M	Protocol: Held-out human-versus-virus protein classification (human-versus-viral protein classification) Dataset: human and viral proteins	94.72% Accur. percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · source checked Methods, coverage and source ESM2 8M: Held-out human-versus-virus protein classification Compare protein origin classifiers; T 5 embeddings plus linear/tree models vs ESM 2 fine-tuning and simple controls. UniRef90 deduplication; proteins longer than1,600 residues excluded; UniRef50 clusters assigned80% training and20% test with no cluster shared. Separate four-fold error-analysis experiment not assigned toTable1. Aggregation: Not reported Protein Language Models Expose Viral Immune Mimicry · Table 1, row ESM2 8M, column Accur.; XML row4 column3
Configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR substitution assay Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay	0.394 AUC dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported ESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.AUC
Configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR substitution assay Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay	-0.139 MCC dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported ESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC
Configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR substitution assay Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay	0.440 NDCG dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported ESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.NDCG
Configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR substitution assay Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay	-0.209 Spearman dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported ESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.Spearman
Configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)	Protocol: ProteinGym v1.3 AMFR substitution assay Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay	0.057 Top_recall dimensionless · higher Uncertainty: Not reported Coverage: 2972/2972	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay ProteinGym v1.3 AMFR substitution assay Aggregation: Not reported ESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.Top_recall
Configuration: ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) (FLIP2 Rhomax by_wild_type)	Protocol: FLIP2 Rhomax by_wild_type Dataset subset: FLIP2 Rhomax by_wild_type test subset	0.8964799835636942 ndcg dimensionless · higher Uncertainty: Not reported Coverage: 184/184	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) on FLIP2 Rhomax by_wild_type FLIP2 Rhomax by_wild_type Aggregation: Not reported ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire): report; ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire): audit · metrics.ndcg
Configuration: ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) (FLIP2 Rhomax by_wild_type)	Protocol: FLIP2 Rhomax by_wild_type Dataset subset: FLIP2 Rhomax by_wild_type test subset	-0.1463506755340845 spearman dimensionless · higher Uncertainty: Not reported Coverage: 184/184	Rewire evaluation · source checked Methods, coverage and source ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) on FLIP2 Rhomax by_wild_type FLIP2 Rhomax by_wild_type Aggregation: Not reported ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire): report; ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire): audit · metrics.spearman

Source checking is not independent reproduction. Release 2026-09-23-2b89723c6dd9.

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How it works, versions and access

Related profile: ESM-2. This page retains the exact record and its evaluation context.

Versions and evaluated configurations

ESM2 8M · family
ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay) · family
ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) (FLIP2 Rhomax by_wild_type) · family

How it works

ESM-2 tokenizes an amino-acid sequence and uses a transformer encoder trained to recover masked residues. Self-attention lets each residue representation depend on its sequence context. The released model returns token probabilities and embeddings; a specified pooling rule, task head or complete folding pipeline is needed for a particular biological prediction.

Sources (3)

Versions and reproducibility

ESM-2 checkpoint identifiers encode layer count, parameter scale and training-data tag. The checked esm2_t33_650M_UR50D configuration lists max_position_embeddings=1,026. This configuration field includes model positions and is not a claim of training or validated inference on 1,026 amino acids.

Sources (3)

Strengths, limitations and unresolved questions

Strengths and limitations

Strengths supported by sources

Released checkpoints span several sizes and can be used without constructing a multiple sequence alignment.
Sources (3)
facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json

Limitations and conditions

A general embedding is not a directly measured function or structure. Fine-tuning, pooling and downstream heads remain part of each evaluated configuration.
Sources (3)
facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json

Profile review details

Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied.

Stable record: catalog-model-esm-2

Specifications

Inputs, training, access and other details

Explanatory profile: source reviewed · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Inputs, outputs and configuration
Property	Description and evidence
Model type	Masked-token protein transformer encoder Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Architecture	Masked-token protein transformer encoder; the checked 650M checkpoint has 33 layers, hidden width 1,280, 20 attention heads and rotary positional encoding. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Inputs	Single amino-acid sequences. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Outputs	Residue embeddings, sequence representations and masked-token predictions. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Parameters	Released scales: 8M, 35M, 150M, 650M, 3B and 15B. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Known versions	ESM-2 checkpoint identifiers encode layer count, parameter scale and training-data tag. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Training data	UniRef50 clusters with UniRef90 sampling; the pretrained-model table labels UR50/D 2021_04. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Training cutoff	The pretrained-model table identifies training-data release UR50/D 2021_04; a corpus release date is not necessarily a last-deposited-sequence cutoff. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Context limits	The checked esm2_t33_650M_UR50D configuration lists max_position_embeddings=1,026. This configuration field includes model positions and is not a claim of training or validated inference on 1,026 amino acids. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Weights licence	The official facebook/esm2_t33_650M_UR50D model card declares MIT; this is the inspected checkpoint, not a licence inference from source code. Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Access	Official project documentation and implementation: https://github.com/facebookresearch/esm Sources (3) facebookresearch/esm: README.md; facebook/esm2_t33_650M_UR50D: README.md; facebook/esm2_t33_650M_UR50D: config.json · ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json
Code licence	MIT Sources facebookresearch/esm: LICENSE · LICENSE: licence text

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

59 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-23-2b89723c6dd9
Property and statement	Original source and location	Review and provenance
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	facebook/esm2_t33_650M_UR50D: config.json Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `539095c22efc52a09d6147074ba4ca119f76a890df5901213b2b55f7d2f96b2b` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	facebookresearch/esm: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac Retrieved: 2026-09-16T19:46:19.090082+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `8b273c21a322fc9473d1b68d0dd40c8166ab2f89e4a190aa26ca87251b97cba9` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram caption Conceptual summary of the documented data flow; optional inputs and configured downstream stages must be reported for a reproducible evaluation. Individual claims	facebook/esm2_t33_650M_UR50D: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.caption` Source artifact SHA-256: `462a2f24724e19c6be0efab926315c294a863c9a9770e2c8b3d859b2d81a07de` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Protein sequence Transformer layers Residue embeddings Specified downstream analysis Individual claims	facebook/esm2_t33_650M_UR50D: config.json Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `539095c22efc52a09d6147074ba4ca119f76a890df5901213b2b55f7d2f96b2b` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Protein sequence Transformer layers Residue embeddings Specified downstream analysis Individual claims	facebookresearch/esm: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac Retrieved: 2026-09-16T19:46:19.090082+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `8b273c21a322fc9473d1b68d0dd40c8166ab2f89e4a190aa26ca87251b97cba9` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram steps Protein sequence Transformer layers Residue embeddings Specified downstream analysis Individual claims	facebook/esm2_t33_650M_UR50D: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.steps` Source artifact SHA-256: `462a2f24724e19c6be0efab926315c294a863c9a9770e2c8b3d859b2d81a07de` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM-2 workflow Individual claims	facebook/esm2_t33_650M_UR50D: config.json Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `539095c22efc52a09d6147074ba4ca119f76a890df5901213b2b55f7d2f96b2b` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM-2 workflow Individual claims	facebookresearch/esm: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac Retrieved: 2026-09-16T19:46:19.090082+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `8b273c21a322fc9473d1b68d0dd40c8166ab2f89e4a190aa26ca87251b97cba9` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Diagram title ESM-2 workflow Individual claims	facebook/esm2_t33_650M_UR50D: README.md Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.diagram.title` Source artifact SHA-256: `462a2f24724e19c6be0efab926315c294a863c9a9770e2c8b3d859b2d81a07de` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact
Model type Masked-token protein transformer encoder Individual claims	facebook/esm2_t33_650M_UR50D: config.json Original source ↗ ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 08e4846e537177426273712802403f7ba8261b6c Retrieved: 2026-09-16T20:04:02.230771+00:00	source checked automated source review · 2026-09-16 Audit details Inspected pinned official documentation, relevant implementation files and named primary-paper sections. Claims are limited to those artifacts. Remaining field extraction and identity conflicts are explicit; no new performance claims, model runs or human review are implied. Field: `attributes.profile.facts.0.value` Source artifact SHA-256: `539095c22efc52a09d6147074ba4ca119f76a890df5901213b2b55f7d2f96b2b` Hash scope: SHA-256 of retrieved original artifact bytes Format: original_artifact Inspected artifact

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Release 2026-09-23-2b89723c6dd9 · Record review: discovered

5 source records and release history

ESM-2 official resource · Original source · Not reported
facebookresearch/esm: README.md · Original source · 2b369911bb5b4b0dda914521b9475cad1656b2ac
facebook/esm2_t33_650M_UR50D: README.md · Original source · 08e4846e537177426273712802403f7ba8261b6c
facebook/esm2_t33_650M_UR50D: config.json · Original source · 08e4846e537177426273712802403f7ba8261b6c
facebookresearch/esm: LICENSE · Original source · 2b369911bb5b4b0dda914521b9475cad1656b2ac

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Technical metadata and extraction receipts

Stable ID: catalog-model-esm-2

areas: proteins-complexes
method types: foundation model
entity level: family
version: 8M
reported name: ESM-2
access: Public checkpoint; small 8M variant suits a local pilot.
method type: foundation model
historical missing metadata: checkpoint revision: not_yet_extracted; training data: not_yet_extracted; licence: not_yet_extracted
metadata review scope: historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
entity classification: review date: 2026-09-17; rationale: The cited profile describes a named learned biological predictor or representation model/family. Preserve this identity separately from task-specific fitting, individual checkpoints, pipelines and hosted access.; source ids: evidence-official-29d4b229a3aa426a6dfb; evidence-official-d7e5c63feb0e0e627625; evidence-official-28fc17fbe0c1d99da219; source locator: ESM README: Pre-trained Models and Main models; official facebook/esm2_t33_650M_UR50D README licence metadata and config.json; ambiguities: None recorded

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variant of: ESM-2
family: ESM2 8M
subject: ESM-2: variant of ESM-2
family: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)
family: ESM-2 8M frozen residue-mean embeddings + fixed ridge (Rewire) (FLIP2 Rhomax by_wild_type)

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