Orthrus

Overview

Prior mRNABench evaluated pipeline, quoted in MIMIC Table S11; not a new execution.

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Evaluations and results

7 evaluations · 7 metric rows. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes eCLIP: eCLIP prediction Dataset subset: mRNABench eCLIP as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.465 auprc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes eCLIP: eCLIP prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 2 (eCLIP)
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes GO: GO prediction Dataset subset: mRNABench GO as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.435 auprc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes GO: GO prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 3 (GO)
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes MRL (LBKWK): MRL (LBKWK) prediction Dataset subset: mRNABench MRL (LBKWK) as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.633 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes MRL (LBKWK): MRL (LBKWK) prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 6 (MRL (LBKWK))
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes MRL (Sugimoto): MRL (Sugimoto) prediction Dataset subset: mRNABench MRL (Sugimoto) as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.460 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes MRL (Sugimoto): MRL (Sugimoto) prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 7 (MRL (Sugimoto))
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes Protein Localization: Protein Localization prediction Dataset subset: mRNABench Protein Localization as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.396 auprc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes Protein Localization: Protein Localization prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 4 (Protein Localization)
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes RNA Half Life: RNA Half Life prediction Dataset subset: mRNABench RNA Half Life as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.696 pearson_r correlation · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes RNA Half Life: RNA Half Life prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 8 (RNA Half Life)
Pipeline: Orthrus	Protocol: MIMIC mRNABench probes RNA Localization: RNA Localization prediction Dataset subset: mRNABench RNA Localization as reported in MIMIC Table S11 (MIMIC mRNABench probes split)	0.789 auprc fraction · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Result quoted from another source · source checked Methods, coverage and source Orthrus on MIMIC mRNABench probes RNA Localization: RNA Localization prediction MIMIC uses concatenated register tokens and mean-pooled RNA-track representations with supervised probes. Nucleotide/codon/amino-acid conditioning is selected per task on validation data; predictions are averaged across selected modality subsets. Comparator scores are quoted from prior mRNABench work. Aggregation: Not reported MIMIC v1: Table S11 and Appendix D.3 · Table S11 (HTML A4.T11), data row 10 (Orthrus [ 74 ]), column 5 (RNA Localization)

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