rewire.it
Task

RNA secondary structure

RNA secondary-structure prediction evaluates proposed nucleotide pairing rather than complete three-dimensional geometry.

Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

40 evaluations · 160 metric rows

At a glance

Inputs, training, access and other details

Explanatory profile: source reviewed · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
Entity typeTask guide; concrete protocol identities remain separate.
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
DatasetsNo single dataset is fixed by this guide. Select a linked protocol and its versioned data release. · Not applicable
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
OrganismsNo shared organism population is defined at this guide level. Record it for each selected dataset. · Not applicable
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
AssaysNo single measurement assay is fixed by this guide; the endpoint and assay belong to the selected protocol. · Not applicable
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
SplitsNo executable split is attached to this task identity. Use the selected protocol’s split manifest. · Not applicable
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
Allowed inputsRNA sequence and any permitted auxiliary information; reference secondary-structure labels for scoring.
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
AdaptationNo common fitting regime is imposed here. Keep pretrained, frozen, probed, fine-tuned and conventional methods distinct where applicable. · Not applicable
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
MetricsPairing or secondary-structure metrics from the selected protocol. This guide defines no common pseudoknot policy, matching tolerance or aggregation.
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
BaselinesCompare the learned predictor with the conventional folding or learned baselines of the concrete task; do not infer a measured result from model availability.
Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

How it works

How it worksConceptual evaluation workflow
Conceptual evaluation workflow1. Select RNA references and split. Then: 2. Declare permitted sequence context. Then: 3. Predict pairing structure. Then: 4. Apply the declared matching and scoringConceptual evaluation workflow1. Select RNA references and split. Then: 2. Declare permitted sequence context. Then: 3. Predict pairing structure. Then: 4. Apply the declared matching and scoringConceptual evaluation workflow1. Select RNA references and split. Then: 2. Declare permitted sequence context. Then: 3. Predict pairing structure. Then: 4. Apply the declared matching and scoring

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
Choosing an evaluation

Use reference pairing labels and a declared scoring rule. BEACON includes a dedicated secondary-structure task, while RNA-FM supplies representations and pairing-related outputs used by downstream models. A representation, a pairing predictor and a complete benchmark are different records. Keep sequence-family overlap and reference-label construction visible.

Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
Task scope

This is a task guide, not a single versioned benchmark protocol. The connected resources provide examples or concrete procedures. A candidate method or proposed control is not evidence that an evaluation has been completed.

Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Evaluation design

Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.

These source-backed links do not make different protocols or scores interchangeable.

Published comparisons

Explore the results reported under one evaluation protocol. Each figure keeps its source, dataset and metric together; it is not a ranking across studies.

bpRNA-TS0 · INF

INF (unitless) · Higher values are better for this metric.

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Evaluation protocol · bpRNA-TS0

  1. BPfold · Configuration · Author-reported evaluation0.670
  2. SPOT-RNA · Configuration · Independent external evaluation0.634
  3. MXfold2 · Configuration · Independent external evaluation0.587
  4. ContextFold · Configuration · Independent external evaluation0.526
  5. CONTRAfold · Configuration · Independent external evaluation0.557
  6. EternaFold · Configuration · Independent external evaluation0.553
  7. LinearFold · Configuration · Independent external evaluation0.539
  8. RNAfold · Configuration · Independent external evaluation0.522
  9. SimFold · Configuration · Independent external evaluation0.520
  10. RNAstructure · Configuration · Independent external evaluation0.520

Source order is preserved. Plotted marks show point estimates; uncertainty, where reported, is retained in the printed values and table. Differences do not establish statistical significance.

Deep generalizable prediction of RNA secondary structure via base pair motif energy · Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF
Values, uncertainty and evidence
INF: original source values
Tested entityPrinted valueUncertaintyEvidence
BPfold · Configuration0.670 unitlessNot reportedAuthor-reported evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF
SPOT-RNA · Configuration0.634 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF
MXfold2 · Configuration0.587 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF
ContextFold · Configuration0.526 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF
CONTRAfold · Configuration0.557 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF
EternaFold · Configuration0.553 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF
LinearFold · Configuration0.539 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF
RNAfold · Configuration0.522 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF
SimFold · Configuration0.520 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF
RNAstructure · Configuration0.520 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF
Scope and limitations
  • Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.

Source transcription and grouping reviewed by automated source review on 2026-09-17. These experiments were not independently reproduced by rewire.

Tested entities and results

Release 2026-09-17-d277315f7d76 · 40 evaluations · 160 metric rows. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
BPfold: RNA secondary structure

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.814 F1

Unit: unitless · Direction: higher

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2, BPfold row, PDB F1 column

Source checking is not independent reproduction.

RNAfold: RNA secondary structure

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.747 F1

Unit: unitless · Direction: higher

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2, RNAfold row, PDB F1 column

Source checking is not independent reproduction.

0.776 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 10 RNAfold, column 8: PDB Precision

Source checking is not independent reproduction.

MXfold2: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.733 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 9: PDB Recall

Source checking is not independent reproduction.

BPfold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.823 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 6: ArchiveII INF

Source checking is not independent reproduction.

0.834 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 9: ArchiveII Recall

Source checking is not independent reproduction.

MXfold2: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.632 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 4: Rfam12.3–14.10 Precision

Source checking is not independent reproduction.

0.664 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 3: Rfam12.3–14.10 F1

Source checking is not independent reproduction.

BPfold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.670 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF

Source checking is not independent reproduction.

0.599 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 4: bpRNA-TS0 Precision

Source checking is not independent reproduction.

EternaFold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.539 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 8 EternaFold, column 3: bpRNA-TS0 F1

Source checking is not independent reproduction.

CONTRAfold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.702 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 7 CONTRAfold, column 5: Rfam12.3–14.10 Recall

Source checking is not independent reproduction.

ContextFold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.824 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 8: ArchiveII Precision

Source checking is not independent reproduction.

CONTRAfold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.557 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF

Source checking is not independent reproduction.

ContextFold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.477 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 4: bpRNA-TS0 Precision

Source checking is not independent reproduction.

CONTRAfold: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.708 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 7 CONTRAfold, column 9: PDB Recall

Source checking is not independent reproduction.

RNAfold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.577 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 7: ArchiveII F1

Source checking is not independent reproduction.

0.551 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 8: ArchiveII Precision

Source checking is not independent reproduction.

SimFold: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.739 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 11 SimFold, column 6: PDB INF

Source checking is not independent reproduction.

SPOT-RNA: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.730 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 4 SPOT-RNA, column 7: ArchiveII F1

Source checking is not independent reproduction.

RNAstructure: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.507 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 12 RNAstructure, column 3: bpRNA-TS0 F1

Source checking is not independent reproduction.

SPOT-RNA: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.678 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 4 SPOT-RNA, column 4: Rfam12.3–14.10 Precision

Source checking is not independent reproduction.

0.672 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 4 SPOT-RNA, column 3: Rfam12.3–14.10 F1

Source checking is not independent reproduction.

EternaFold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.672 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 8 EternaFold, column 2: Rfam12.3–14.10 INF

Source checking is not independent reproduction.

RNAfold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.729 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 10 RNAfold, column 5: Rfam12.3–14.10 Recall

Source checking is not independent reproduction.

Papers and result coverage

Last literature check: 2026-09-17. Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.

Search and extraction details

complete tables extracted

Searches

  • Deep generalizable prediction of RNA secondary structure via base pair motif energy 10.1038/s41467-025-60048-1

Evidence locations

  • BPfold Tables 1–2; Methods, Evaluation metrics

Strengths and limitations

Limitations and conditions

  • Secondary-structure accuracy does not establish tertiary-structure accuracy, and close sequence relatives can weaken a claimed generalisation test.
    Sources (2)terry-r123/RNABenchmark official source; ml4bio/RNA-FM official source · BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs
Profile review details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Stable record: catalog-task-rna-secondary-structure

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

34 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Individual claims
ml4bio/RNA-FM official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Diagram caption

Conceptual task guide. Dataset preparation, parameters and scoring must come from a separately identified protocol.

Individual claims
terry-r123/RNABenchmark official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: da7f9c7ac3f39605af27e1dfcdf879adba963d79
Retrieved: 2026-09-16T10:30:21.025462+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 0403f84453aace301c7d02895d94a977ccbbec77c3a94a49a23d0d529dd48d31

Hash scope: Hash scope not separately documented; inspect source record

Diagram steps

["Select RNA references and split","Declare permitted sequence context","Predict pairing structure","Apply the declared matching and scoring"]

Individual claims
ml4bio/RNA-FM official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Diagram steps

["Select RNA references and split","Declare permitted sequence context","Predict pairing structure","Apply the declared matching and scoring"]

Individual claims
terry-r123/RNABenchmark official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: da7f9c7ac3f39605af27e1dfcdf879adba963d79
Retrieved: 2026-09-16T10:30:21.025462+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 0403f84453aace301c7d02895d94a977ccbbec77c3a94a49a23d0d529dd48d31

Hash scope: Hash scope not separately documented; inspect source record

Diagram title

Conceptual evaluation workflow

Individual claims
ml4bio/RNA-FM official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.title

Source artifact SHA-256: f9f1c1d62adc471661ca98b30c0250e9f3ce0cff7433830f149f5f48ea41c3da

Hash scope: Hash scope not separately documented; inspect source record

Diagram title

Conceptual evaluation workflow

Individual claims
terry-r123/RNABenchmark official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: da7f9c7ac3f39605af27e1dfcdf879adba963d79
Retrieved: 2026-09-16T10:30:21.025462+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 0403f84453aace301c7d02895d94a977ccbbec77c3a94a49a23d0d529dd48d31

Hash scope: Hash scope not separately documented; inspect source record

Entity type

Task guide; concrete protocol identities remain separate.

Individual claims
ml4bio/RNA-FM official source

Original source ↗

BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 348951516e0963d22bbb33b3c9fc18c89081d38e
Retrieved: 2026-09-16T10:30:26.372370+00:00

source checked

automated source review · 2026-09-16

Audit details

Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

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Task guide; concrete protocol identities remain separate.

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terry-r123/RNABenchmark official source

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BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

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source checked

automated source review · 2026-09-16

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ml4bio/RNA-FM official source

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BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

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inapplicable

automated source review · 2026-09-16

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Reviewed named primary documentation and existing protocol records. Editorial task scope is distinguished from source-reported procedures. No model execution or new numerical result; a reviewed guide is not a complete runnable protocol.

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terry-r123/RNABenchmark official source

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BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs

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inapplicable

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Release 2026-09-17-d277315f7d76 · Record review: discovered

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Technical metadata and extraction receipts

Stable ID: catalog-task-rna-secondary-structure

areas
rna-transcriptomes
entity level
task
version
Not reported
task
RNA secondary structure
scope note
Compare predicted base pairs against held-out RNA structures.
comparison panels
id: bpfold-2025-tab1-bprna-ts0-inf; title: bpRNA-TS0 · INF; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: INF; unit: unitless; direction: higher; result ids: paper-result-0458271bb982e75179; paper-result-5a1624fdb7640263f2; paper-result-7b916d75babf7a4d06; paper-result-e8e6954c70547446a1; paper-result-0da7bdbbf7b43c8456; paper-result-5249c6fca0adf30079; paper-result-5ebc9d5244115922e3; paper-result-66830706f75e525dbf; paper-result-711a4c604b04a9b0f2; paper-result-53887e7500c1cf009e; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-f1; title: bpRNA-TS0 · F1; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: F1; unit: unitless; direction: higher; result ids: paper-result-f0f7111a6ec6426675; paper-result-4cd8df587d039cd7e1; paper-result-a5fe28b91e06263870; paper-result-8a436775a6db0626a1; paper-result-681cbde13cc79ef7ca; paper-result-0a1d1b57a38ce34e75; paper-result-35d6ca02cce090966b; paper-result-dcf0e23f78d1cb6fc0; paper-result-c536ed0e0b21471c4e; paper-result-1ccf4abe34808409ff; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 4 SPOT-RNA, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 5 MXfold2, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 6 ContextFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 7 CONTRAfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 8 EternaFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 9 LinearFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 10 RNAfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 11 SimFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 12 RNAstructure, column 3: bpRNA-TS0 F1; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-precision; title: bpRNA-TS0 · Precision; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-11c1675cb5828808ab; paper-result-cb40146a919da9086a; paper-result-b78905513200ad10fe; paper-result-1069d4f8df9404d6e5; paper-result-deff3015ebe9868640; paper-result-5efbf1aebc52ee2283; paper-result-62e9fb6e2b7036a5d5; paper-result-ce1b188daa1f9f9fa6; paper-result-d7b4db6a7311486ac5; paper-result-bae3bdb96c31f1a771; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 4 SPOT-RNA, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 5 MXfold2, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 6 ContextFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 7 CONTRAfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 8 EternaFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 9 LinearFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 10 RNAfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 11 SimFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 12 RNAstructure, column 4: bpRNA-TS0 Precision; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-recall; title: bpRNA-TS0 · Recall; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-84076a2caea4d91a05; paper-result-362a0ed0c13044cdfc; paper-result-9fcdf129530b83f00e; paper-result-b31f8dc93eb733d9c3; paper-result-889ce61bcef60c0f8c; paper-result-3b51165690d6d453ee; paper-result-c785e6f619ae381da7; paper-result-7b019b2b8bb9da3d29; paper-result-725d822668ea6d7acd; paper-result-d7a88bfa84a1748144; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 4 SPOT-RNA, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 5 MXfold2, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 6 ContextFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 7 CONTRAfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 8 EternaFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 9 LinearFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 10 RNAfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 11 SimFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 12 RNAstructure, column 5: bpRNA-TS0 Recall; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-inf; title: ArchiveII · INF; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: INF; unit: unitless; direction: higher; result ids: paper-result-0201b139fce549eab3; paper-result-74f904c36aab24aa79; paper-result-4800ab44874448c8b4; paper-result-fcd63eea1286d760ab; paper-result-e6a6c3931d9266f05f; paper-result-9b4f92609217cc1fb6; paper-result-9110b71d1f8e197959; paper-result-ded0df417ed95f9f29; paper-result-e32db43eda24866957; paper-result-45847f62623b463cf2; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 6: ArchiveII INF; Table 1 (Tab1), row 4 SPOT-RNA, column 6: ArchiveII INF; Table 1 (Tab1), row 5 MXfold2, column 6: ArchiveII INF; Table 1 (Tab1), row 6 ContextFold, column 6: ArchiveII INF; Table 1 (Tab1), row 7 CONTRAfold, column 6: ArchiveII INF; Table 1 (Tab1), row 8 EternaFold, column 6: ArchiveII INF; Table 1 (Tab1), row 9 LinearFold, column 6: ArchiveII INF; Table 1 (Tab1), row 10 RNAfold, column 6: ArchiveII INF; Table 1 (Tab1), row 11 SimFold, column 6: ArchiveII INF; Table 1 (Tab1), row 12 RNAstructure, column 6: ArchiveII INF; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-f1; title: ArchiveII · F1; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: F1; unit: unitless; direction: higher; result ids: paper-result-848e79a6dda494f6d2; paper-result-15bf14f0627ace6e51; paper-result-b261f94a241a11866c; paper-result-f6296b4b6029ae0c24; paper-result-4966fd60b18e79a44a; paper-result-3f5f78f9847ba7def0; paper-result-64436b2115ee5881b4; paper-result-145bc6b041b9d5dbe4; paper-result-61f86306875259316e; paper-result-8d618367d005102a41; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 7: ArchiveII F1; Table 1 (Tab1), row 4 SPOT-RNA, column 7: ArchiveII F1; Table 1 (Tab1), row 5 MXfold2, column 7: ArchiveII F1; Table 1 (Tab1), row 6 ContextFold, column 7: ArchiveII F1; Table 1 (Tab1), row 7 CONTRAfold, column 7: ArchiveII F1; Table 1 (Tab1), row 8 EternaFold, column 7: ArchiveII F1; Table 1 (Tab1), row 9 LinearFold, column 7: ArchiveII F1; Table 1 (Tab1), row 10 RNAfold, column 7: ArchiveII F1; Table 1 (Tab1), row 11 SimFold, column 7: ArchiveII F1; Table 1 (Tab1), row 12 RNAstructure, column 7: ArchiveII F1; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-precision; title: ArchiveII · Precision; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-cab7a52a6159f4b3f5; paper-result-4e6b9de9fa6581febe; paper-result-4e335c3e3fc60bd7a3; paper-result-0d6f9ea5b80a61c517; paper-result-6fd617ba744c55f823; paper-result-80618ad04474cfdfa4; paper-result-d0f2c61c9603a219fd; paper-result-2bf7f6f35cb278b8b3; paper-result-b4a0a133d3c57bbd78; paper-result-af213ccd00f688f0e8; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 4 SPOT-RNA, column 8: ArchiveII Precision; Table 1 (Tab1), row 5 MXfold2, column 8: ArchiveII Precision; Table 1 (Tab1), row 6 ContextFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 7 CONTRAfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 8 EternaFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 9 LinearFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 10 RNAfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 11 SimFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 12 RNAstructure, column 8: ArchiveII Precision; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-recall; title: ArchiveII · Recall; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-23d3090d9e3540349d; paper-result-b79992ef838378f5c1; paper-result-e038536d6f9b001984; paper-result-d82764605cdb73aad8; paper-result-57de4fbe015fbae501; paper-result-a8cf704b852f820e32; paper-result-5f273213a7f48d1b55; paper-result-8164922a733ea800eb; paper-result-ccd93245b92c3d3620; paper-result-cf786103471c989dd3; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 4 SPOT-RNA, column 9: ArchiveII Recall; Table 1 (Tab1), row 5 MXfold2, column 9: ArchiveII Recall; Table 1 (Tab1), row 6 ContextFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 7 CONTRAfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 8 EternaFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 9 LinearFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 10 RNAfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 11 SimFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 12 RNAstructure, column 9: ArchiveII Recall; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-inf; title: Rfam12.3–14.10 · INF; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: INF; unit: unitless; direction: higher; result ids: paper-result-bc33c532295af7b251; paper-result-d3521184aa90f4092f; paper-result-625df7ddcc5441ab69; paper-result-ae0e3455f6b89e6f70; paper-result-57fc7701f0c9da77d0; paper-result-26e74e5c77ce1570a9; paper-result-ad4f1a6205fecd1b6d; paper-result-d197148a19effcf018; paper-result-68b0000887cc4b5e80; paper-result-853e1b3f8354ef0290; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 4 SPOT-RNA, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 5 MXfold2, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 6 ContextFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 7 CONTRAfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 8 EternaFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 9 LinearFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 10 RNAfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 11 SimFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 12 RNAstructure, column 2: Rfam12.3–14.10 INF; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-f1; title: Rfam12.3–14.10 · F1; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: F1; unit: unitless; direction: higher; result ids: paper-result-d8fb52a660fba363da; paper-result-3019f81982dc6332cf; paper-result-0ce94efc1ed30c3769; paper-result-a34fce1d750df98700; paper-result-ac79fb8c90b25f7318; paper-result-3db670da1582c96f89; paper-result-f60a9b4fba0bdd5bca; paper-result-5c3a3c43a76fcaeb84; paper-result-7f0004110bb610598b; paper-result-31c527dabf4e1f6958; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 4 SPOT-RNA, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 5 MXfold2, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 6 ContextFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 7 CONTRAfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 8 EternaFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 9 LinearFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 10 RNAfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 11 SimFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 12 RNAstructure, column 3: Rfam12.3–14.10 F1; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-precision; title: Rfam12.3–14.10 · Precision; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-4c05190191ba52c1d1; paper-result-22774caf06553a0120; paper-result-03b61894f52b9f6a21; paper-result-39a55efc7440a14e65; paper-result-c859a2ad30d5982c35; paper-result-d49a44e7ee0390f25d; paper-result-6e6c7831c443afa6ed; paper-result-e59816ecb58e31617e; paper-result-b6a697b1154c255641; paper-result-f3fb35d7219cc3367e; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 4 SPOT-RNA, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 5 MXfold2, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 6 ContextFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 7 CONTRAfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 8 EternaFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 9 LinearFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 10 RNAfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 11 SimFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 12 RNAstructure, column 4: Rfam12.3–14.10 Precision; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-recall; title: Rfam12.3–14.10 · Recall; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-399712a182e4786639; paper-result-c824c3c83e5e451637; paper-result-a1f081e3b661ff4c25; paper-result-99b4cc2229fcdd0626; paper-result-0c3b54bf620bf11af3; paper-result-b94255fbaa7ff64d55; paper-result-453956286dc654a2fc; paper-result-30d6b97036164e9290; paper-result-c7d3e722ba9b016c03; paper-result-975ccfae7d5107a44a; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 4 SPOT-RNA, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 5 MXfold2, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 6 ContextFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 7 CONTRAfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 8 EternaFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 9 LinearFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 10 RNAfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 11 SimFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 12 RNAstructure, column 5: Rfam12.3–14.10 Recall; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-inf; title: PDB · INF; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: INF; unit: unitless; direction: higher; result ids: paper-result-97b54396c089187bac; paper-result-5465552e8e451ecd56; paper-result-e465e8b97a72acc635; paper-result-d1041275466a1cb1ae; paper-result-3d0a9108d41aebb9db; paper-result-3ddc4380f7d4e8cc34; paper-result-738dbc58785cabadb7; paper-result-c2cbc18894bd07f1a6; paper-result-155bc3cd1981f1e9fd; paper-result-cfbfd2a82ace58ed84; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 6: PDB INF; Table 2 (Tab2), row 4 SPOT-RNA, column 6: PDB INF; Table 2 (Tab2), row 5 MXfold2, column 6: PDB INF; Table 2 (Tab2), row 6 ContextFold, column 6: PDB INF; Table 2 (Tab2), row 7 CONTRAfold, column 6: PDB INF; Table 2 (Tab2), row 8 EternaFold, column 6: PDB INF; Table 2 (Tab2), row 9 LinearFold, column 6: PDB INF; Table 2 (Tab2), row 10 RNAfold, column 6: PDB INF; Table 2 (Tab2), row 11 SimFold, column 6: PDB INF; Table 2 (Tab2), row 12 RNAstructure, column 6: PDB INF; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-f1; title: PDB · F1; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: F1; unit: unitless; direction: higher; result ids: lit-011; paper-result-57c0ff7b77a652ab1c; paper-result-3d2877af386639e0ad; paper-result-4ae34e1cc310c60554; paper-result-b6a3c4b03b40732ef2; paper-result-96d2c93b67543eaa47; paper-result-9440f5e0b35b26980b; lit-012; paper-result-fda0f45ba9232f7233; paper-result-c35bfeb0f7fc67fda6; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 7: PDB F1; Table 2 (Tab2), row 4 SPOT-RNA, column 7: PDB F1; Table 2 (Tab2), row 5 MXfold2, column 7: PDB F1; Table 2 (Tab2), row 6 ContextFold, column 7: PDB F1; Table 2 (Tab2), row 7 CONTRAfold, column 7: PDB F1; Table 2 (Tab2), row 8 EternaFold, column 7: PDB F1; Table 2 (Tab2), row 9 LinearFold, column 7: PDB F1; Table 2 (Tab2), row 10 RNAfold, column 7: PDB F1; Table 2 (Tab2), row 11 SimFold, column 7: PDB F1; Table 2 (Tab2), row 12 RNAstructure, column 7: PDB F1; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-precision; title: PDB · Precision; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-8319fb26cf3f85d194; paper-result-eac4aa84532a86e39b; paper-result-b6a55e179b51c6398e; paper-result-5ae72ffe6dc5e67fcd; paper-result-d4877662e8f67af294; paper-result-49bafa3b1c623a5f8d; paper-result-c96dd6eb50a381f576; paper-result-2d080d038082cd24e2; paper-result-ddafb4472501414293; paper-result-c9d2c92f2b018f5062; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 8: PDB Precision; Table 2 (Tab2), row 4 SPOT-RNA, column 8: PDB Precision; Table 2 (Tab2), row 5 MXfold2, column 8: PDB Precision; Table 2 (Tab2), row 6 ContextFold, column 8: PDB Precision; Table 2 (Tab2), row 7 CONTRAfold, column 8: PDB Precision; Table 2 (Tab2), row 8 EternaFold, column 8: PDB Precision; Table 2 (Tab2), row 9 LinearFold, column 8: PDB Precision; Table 2 (Tab2), row 10 RNAfold, column 8: PDB Precision; Table 2 (Tab2), row 11 SimFold, column 8: PDB Precision; Table 2 (Tab2), row 12 RNAstructure, column 8: PDB Precision; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-recall; title: PDB · Recall; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-5afb76a439dd9677b9; paper-result-3ad0144bc78eae6759; paper-result-01efc77bc3fe0c8593; paper-result-5fe58d35cc68e79078; paper-result-11126a2ff54dbf3afb; paper-result-a45e9b5b53f964bd93; paper-result-8828c8e20f56d3d354; paper-result-6f6f94f1d2e661baac; paper-result-a7667b03bef3a87b94; paper-result-c0cf50ee8c90573ad2; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 9: PDB Recall; Table 2 (Tab2), row 4 SPOT-RNA, column 9: PDB Recall; Table 2 (Tab2), row 5 MXfold2, column 9: PDB Recall; Table 2 (Tab2), row 6 ContextFold, column 9: PDB Recall; Table 2 (Tab2), row 7 CONTRAfold, column 9: PDB Recall; Table 2 (Tab2), row 8 EternaFold, column 9: PDB Recall; Table 2 (Tab2), row 9 LinearFold, column 9: PDB Recall; Table 2 (Tab2), row 10 RNAfold, column 9: PDB Recall; Table 2 (Tab2), row 11 SimFold, column 9: PDB Recall; Table 2 (Tab2), row 12 RNAstructure, column 9: PDB Recall; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17
benchmark research
review date: 2026-09-17; status: complete_tables_extracted; primary sources: evidence-expansion-bpfold-2025-976218bd; inspected locators: BPfold Tables 1–2; Methods, Evaluation metrics; searched queries: Deep generalizable prediction of RNA secondary structure via base pair motif energy 10.1038/s41467-025-60048-1; gaps: None recorded; claim scope: Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.
historical missing metadata
protocol version: not_yet_extracted
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This record identifies the biological prediction question or a suite-specific task, rather than a uniquely fixed evaluated procedure. Preserve its task identity and leave split, model adaptation and scoring details on linked protocols/evaluations.; source ids: src-discovery-terry-r123-rnabenchmark; src-discovery-ml4bio-rna-fm; source locator: BEACON README: Tasks and Datasets; RNA-FM README: secondary structure prediction and foundation-model outputs; ambiguities: None recorded
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