rewire.it
Task

RNA secondary structure

RNA secondary-structure prediction is evaluated separately for sequence-level and RNA-family generalization.

SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

40 evaluations · 160 metric rows

At a glance

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
DatasetsArchiveII, bpRNA-TS0, Rfam12.3–14.10 and experimentally grounded PDB50 evaluation collections.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
SplitsThe paper distinguishes sequence-wise assessment from cross-family evaluation.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
MetricsMacro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
BaselinesSPOT-RNA, MXfold2, ContextFold, CONTRAfold, EternaFold, LinearFold, RNAfold, SimFold and RNAstructure.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
Leakage controlsThe bpRNA benchmark applies an 80% sequence-similarity filter. Family-wise testing uses newly added Rfam families absent from the bpRNA training collection and separately removes similar sequences at 80%. Sequence-wise and unseen-family results therefore measure different forms of generalization.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Methods dataset list in full XML; Results: Evaluating BPfold on family-wise datasets; Tables 1–2
UncertaintyA model confidence index is correlated with observed F1; that diagnostic is not a confidence interval for benchmark performance.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
Entity typePaper-specific computational evaluation protocol.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
OrganismsThe evaluation pools RNA-family datasets and PDB RNA structures. The Methods dataset list enumerates RNA families and sequence sets, not taxa. Individual bacterial and viral examples in Figure 6 do not establish the species composition of the aggregate benchmark. · Not reported in inspected sources
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Methods dataset list; Tables 1–2; Fig.6 caption
AssaysRNA secondary-structure references including experimentally grounded PDB structures.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
Allowed inputsRNA sequence.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
AdaptationSupervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.
SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

How it works

How it worksComputational evaluation flow
Computational evaluation flow1. Input: RNA sequence.. Then: 2. Evaluation: Supervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.. Then: 3. Readout: Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions.Computational evaluation flow1. Input: RNA sequence.. Then: 2. Evaluation: Supervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.. Then: 3. Readout: Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions.Computational evaluation flow1. Input: RNA sequence.. Then: 2. Evaluation: Supervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.. Then: 3. Readout: Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions.

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions
Evaluation methodology

ArchiveII, bpRNA-TS0, Rfam12.3–14.10 and experimentally grounded PDB50 evaluation collections. The paper distinguishes sequence-wise assessment from cross-family evaluation. Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions. SPOT-RNA, MXfold2, ContextFold, CONTRAfold, EternaFold, LinearFold, RNAfold, SimFold and RNAstructure. A model confidence index is correlated with observed F1; that diagnostic is not a confidence interval for benchmark performance.

SourcesDeep generalizable prediction of RNA secondary structure via base pair motif energy · Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Evaluation design

Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.

These source-backed links do not make different protocols or scores interchangeable.

Published comparisons

Explore the results reported under one evaluation protocol. Each figure keeps its source, dataset and metric together; it is not a ranking across studies.

bpRNA-TS0 · INF

INF (unitless) · Higher values are better for this metric.

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Evaluation protocol · bpRNA-TS0

  1. BPfold · Configuration · Author-reported evaluation0.670
  2. SPOT-RNA · Configuration · Independent external evaluation0.634
  3. MXfold2 · Configuration · Independent external evaluation0.587
  4. ContextFold · Configuration · Independent external evaluation0.526
  5. CONTRAfold · Configuration · Independent external evaluation0.557
  6. EternaFold · Configuration · Independent external evaluation0.553
  7. LinearFold · Configuration · Independent external evaluation0.539
  8. RNAfold · Configuration · Independent external evaluation0.522
  9. SimFold · Configuration · Independent external evaluation0.520
  10. RNAstructure · Configuration · Independent external evaluation0.520

Source order is preserved. Plotted marks show point estimates; uncertainty, where reported, is retained in the printed values and table. Differences do not establish statistical significance.

Deep generalizable prediction of RNA secondary structure via base pair motif energy · Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF
Values, uncertainty and evidence
INF: original source values
Tested entityPrinted valueUncertaintyEvidence
BPfold · Configuration0.670 unitlessNot reportedAuthor-reported evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF
SPOT-RNA · Configuration0.634 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF
MXfold2 · Configuration0.587 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF
ContextFold · Configuration0.526 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF
CONTRAfold · Configuration0.557 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF
EternaFold · Configuration0.553 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF
LinearFold · Configuration0.539 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF
RNAfold · Configuration0.522 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF
SimFold · Configuration0.520 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF
RNAstructure · Configuration0.520 unitlessNot reportedIndependent external evaluation · source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF
Scope and limitations
  • Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.

Source transcription and grouping reviewed by automated source review on 2026-09-17. These experiments were not independently reproduced by rewire.

Tested entities and results

Release 2026-09-17-d277315f7d76 · 40 evaluations · 160 metric rows. Different protocols are not a single leaderboard.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
BPfold: RNA secondary structure

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.814 F1

Unit: unitless · Direction: higher

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2, BPfold row, PDB F1 column

Source checking is not independent reproduction.

RNAfold: RNA secondary structure

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.747 F1

Unit: unitless · Direction: higher

Uncertainty: not reported in legacy extract

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2, RNAfold row, PDB F1 column

Source checking is not independent reproduction.

0.776 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 10 RNAfold, column 8: PDB Precision

Source checking is not independent reproduction.

MXfold2: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.733 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 9: PDB Recall

Source checking is not independent reproduction.

BPfold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.823 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 6: ArchiveII INF

Source checking is not independent reproduction.

0.834 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 9: ArchiveII Recall

Source checking is not independent reproduction.

MXfold2: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.632 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 4: Rfam12.3–14.10 Precision

Source checking is not independent reproduction.

0.664 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 5 MXfold2, column 3: Rfam12.3–14.10 F1

Source checking is not independent reproduction.

BPfold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Author-reported evaluation · Evaluation metadata: needs review

0.670 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF

Source checking is not independent reproduction.

0.599 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 3 BPfold, column 4: bpRNA-TS0 Precision

Source checking is not independent reproduction.

EternaFold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.539 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 8 EternaFold, column 3: bpRNA-TS0 F1

Source checking is not independent reproduction.

CONTRAfold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.702 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 7 CONTRAfold, column 5: Rfam12.3–14.10 Recall

Source checking is not independent reproduction.

ContextFold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.824 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 8: ArchiveII Precision

Source checking is not independent reproduction.

CONTRAfold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.557 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF

Source checking is not independent reproduction.

ContextFold: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.477 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 6 ContextFold, column 4: bpRNA-TS0 Precision

Source checking is not independent reproduction.

CONTRAfold: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.708 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 7 CONTRAfold, column 9: PDB Recall

Source checking is not independent reproduction.

RNAfold: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.577 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 7: ArchiveII F1

Source checking is not independent reproduction.

0.551 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 10 RNAfold, column 8: ArchiveII Precision

Source checking is not independent reproduction.

SimFold: PDB

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.739 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 11 SimFold, column 6: PDB INF

Source checking is not independent reproduction.

SPOT-RNA: ArchiveII

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.730 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 4 SPOT-RNA, column 7: ArchiveII F1

Source checking is not independent reproduction.

RNAstructure: bpRNA-TS0

Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.507 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 1 (Tab1), row 12 RNAstructure, column 3: bpRNA-TS0 F1

Source checking is not independent reproduction.

SPOT-RNA: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.678 Precision

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 4 SPOT-RNA, column 4: Rfam12.3–14.10 Precision

Source checking is not independent reproduction.

0.672 F1

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 4 SPOT-RNA, column 3: Rfam12.3–14.10 F1

Source checking is not independent reproduction.

EternaFold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.672 INF

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 8 EternaFold, column 2: Rfam12.3–14.10 INF

Source checking is not independent reproduction.

RNAfold: Rfam12.3–14.10

Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.

Independent external evaluation · Evaluation metadata: needs review

0.729 Recall

Unit: unitless · Direction: higher

Uncertainty: unreported

Scored: Not reported · Eligible: Not reported

source checkedDeep generalizable prediction of RNA secondary structure via base pair motif energy · Table 2 (Tab2), row 10 RNAfold, column 5: Rfam12.3–14.10 Recall

Source checking is not independent reproduction.

Papers and result coverage

Last literature check: 2026-09-17. Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.

What is still missing

  • exact checkpoint hashes and per-method scored denominators: Table labels alone do not establish these fields; do not infer checkpoint or scored count from model name or dataset size.
Search and extraction details

complete tables extracted

Searches

  • Deep generalizable prediction of RNA secondary structure via base pair motif energy 10.1038/s41467-025-60048-1

Evidence locations

  • Table 1; XML table Tab1
  • Table 2; XML table Tab2

Strengths and limitations

Strengths and considerations

No source-reviewed explanatory claims are recorded here yet.

Limitations and conditions

Profile review details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Stable record: reported-task-dc82fcbfb44935

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-d277315f7d76
Property and statementOriginal source and locationReview and provenance
Diagram caption

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps

["Input: RNA sequence.","Evaluation: Supervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.","Readout: Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions."]

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title

Computational evaluation flow

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.title

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Datasets

ArchiveII, bpRNA-TS0, Rfam12.3–14.10 and experimentally grounded PDB50 evaluation collections.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Splits

The paper distinguishes sequence-wise assessment from cross-family evaluation.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Adaptation

Supervised sequence-to-structure prediction with separate sequence-wise and cross-family assessments.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Metrics

Macro-averaged precision, recall, F1 and interaction network fidelity on canonical base-pair predictions.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Baselines

SPOT-RNA, MXfold2, ContextFold, CONTRAfold, EternaFold, LinearFold, RNAfold, SimFold and RNAstructure.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Leakage controls

The bpRNA benchmark applies an 80% sequence-similarity filter. Family-wise testing uses newly added Rfam families absent from the bpRNA training collection and separately removes similar sequences at 80%. Sequence-wise and unseen-family results therefore measure different forms of generalization.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Methods dataset list in full XML; Results: Evaluating BPfold on family-wise datasets; Tables 1–2

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Uncertainty

A model confidence index is correlated with observed F1; that diagnostic is not a confidence interval for benchmark performance.

Individual claims
Deep generalizable prediction of RNA secondary structure via base pair motif energy

Original source ↗

Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions

Version: version of record
Retrieved: 2026-09-16T10:41:16.502000+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.5.value

Source artifact SHA-256: 976218bd172998a1a6e7ed1609ecb8cb2ee380fb48a8dc7b25bc05ea8b0a49af

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-09-17-d277315f7d76 · Record review: needs review

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-task-dc82fcbfb44935

areas
rna-transcriptomes
tasks
RNA secondary structure
entity level
task
version
Not reported
task
RNA secondary structure
scope note
Paper-specific evaluation task; protocol completeness requires further extraction.
comparison panels
id: bpfold-2025-tab1-bprna-ts0-inf; title: bpRNA-TS0 · INF; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: INF; unit: unitless; direction: higher; result ids: paper-result-0458271bb982e75179; paper-result-5a1624fdb7640263f2; paper-result-7b916d75babf7a4d06; paper-result-e8e6954c70547446a1; paper-result-0da7bdbbf7b43c8456; paper-result-5249c6fca0adf30079; paper-result-5ebc9d5244115922e3; paper-result-66830706f75e525dbf; paper-result-711a4c604b04a9b0f2; paper-result-53887e7500c1cf009e; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 4 SPOT-RNA, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 5 MXfold2, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 6 ContextFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 7 CONTRAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 8 EternaFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 9 LinearFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 10 RNAfold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 11 SimFold, column 2: bpRNA-TS0 INF; Table 1 (Tab1), row 12 RNAstructure, column 2: bpRNA-TS0 INF; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-f1; title: bpRNA-TS0 · F1; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: F1; unit: unitless; direction: higher; result ids: paper-result-f0f7111a6ec6426675; paper-result-4cd8df587d039cd7e1; paper-result-a5fe28b91e06263870; paper-result-8a436775a6db0626a1; paper-result-681cbde13cc79ef7ca; paper-result-0a1d1b57a38ce34e75; paper-result-35d6ca02cce090966b; paper-result-dcf0e23f78d1cb6fc0; paper-result-c536ed0e0b21471c4e; paper-result-1ccf4abe34808409ff; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 4 SPOT-RNA, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 5 MXfold2, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 6 ContextFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 7 CONTRAfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 8 EternaFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 9 LinearFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 10 RNAfold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 11 SimFold, column 3: bpRNA-TS0 F1; Table 1 (Tab1), row 12 RNAstructure, column 3: bpRNA-TS0 F1; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-precision; title: bpRNA-TS0 · Precision; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-11c1675cb5828808ab; paper-result-cb40146a919da9086a; paper-result-b78905513200ad10fe; paper-result-1069d4f8df9404d6e5; paper-result-deff3015ebe9868640; paper-result-5efbf1aebc52ee2283; paper-result-62e9fb6e2b7036a5d5; paper-result-ce1b188daa1f9f9fa6; paper-result-d7b4db6a7311486ac5; paper-result-bae3bdb96c31f1a771; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 4 SPOT-RNA, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 5 MXfold2, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 6 ContextFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 7 CONTRAfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 8 EternaFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 9 LinearFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 10 RNAfold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 11 SimFold, column 4: bpRNA-TS0 Precision; Table 1 (Tab1), row 12 RNAstructure, column 4: bpRNA-TS0 Precision; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-bprna-ts0-recall; title: bpRNA-TS0 · Recall; protocol id: paper-protocol-208a8085432aa64eb2; dataset id: paper-dataset-9a595197e5581413b6; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-84076a2caea4d91a05; paper-result-362a0ed0c13044cdfc; paper-result-9fcdf129530b83f00e; paper-result-b31f8dc93eb733d9c3; paper-result-889ce61bcef60c0f8c; paper-result-3b51165690d6d453ee; paper-result-c785e6f619ae381da7; paper-result-7b019b2b8bb9da3d29; paper-result-725d822668ea6d7acd; paper-result-d7a88bfa84a1748144; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 4 SPOT-RNA, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 5 MXfold2, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 6 ContextFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 7 CONTRAfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 8 EternaFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 9 LinearFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 10 RNAfold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 11 SimFold, column 5: bpRNA-TS0 Recall; Table 1 (Tab1), row 12 RNAstructure, column 5: bpRNA-TS0 Recall; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-inf; title: ArchiveII · INF; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: INF; unit: unitless; direction: higher; result ids: paper-result-0201b139fce549eab3; paper-result-74f904c36aab24aa79; paper-result-4800ab44874448c8b4; paper-result-fcd63eea1286d760ab; paper-result-e6a6c3931d9266f05f; paper-result-9b4f92609217cc1fb6; paper-result-9110b71d1f8e197959; paper-result-ded0df417ed95f9f29; paper-result-e32db43eda24866957; paper-result-45847f62623b463cf2; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 6: ArchiveII INF; Table 1 (Tab1), row 4 SPOT-RNA, column 6: ArchiveII INF; Table 1 (Tab1), row 5 MXfold2, column 6: ArchiveII INF; Table 1 (Tab1), row 6 ContextFold, column 6: ArchiveII INF; Table 1 (Tab1), row 7 CONTRAfold, column 6: ArchiveII INF; Table 1 (Tab1), row 8 EternaFold, column 6: ArchiveII INF; Table 1 (Tab1), row 9 LinearFold, column 6: ArchiveII INF; Table 1 (Tab1), row 10 RNAfold, column 6: ArchiveII INF; Table 1 (Tab1), row 11 SimFold, column 6: ArchiveII INF; Table 1 (Tab1), row 12 RNAstructure, column 6: ArchiveII INF; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-f1; title: ArchiveII · F1; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: F1; unit: unitless; direction: higher; result ids: paper-result-848e79a6dda494f6d2; paper-result-15bf14f0627ace6e51; paper-result-b261f94a241a11866c; paper-result-f6296b4b6029ae0c24; paper-result-4966fd60b18e79a44a; paper-result-3f5f78f9847ba7def0; paper-result-64436b2115ee5881b4; paper-result-145bc6b041b9d5dbe4; paper-result-61f86306875259316e; paper-result-8d618367d005102a41; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 7: ArchiveII F1; Table 1 (Tab1), row 4 SPOT-RNA, column 7: ArchiveII F1; Table 1 (Tab1), row 5 MXfold2, column 7: ArchiveII F1; Table 1 (Tab1), row 6 ContextFold, column 7: ArchiveII F1; Table 1 (Tab1), row 7 CONTRAfold, column 7: ArchiveII F1; Table 1 (Tab1), row 8 EternaFold, column 7: ArchiveII F1; Table 1 (Tab1), row 9 LinearFold, column 7: ArchiveII F1; Table 1 (Tab1), row 10 RNAfold, column 7: ArchiveII F1; Table 1 (Tab1), row 11 SimFold, column 7: ArchiveII F1; Table 1 (Tab1), row 12 RNAstructure, column 7: ArchiveII F1; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-precision; title: ArchiveII · Precision; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-cab7a52a6159f4b3f5; paper-result-4e6b9de9fa6581febe; paper-result-4e335c3e3fc60bd7a3; paper-result-0d6f9ea5b80a61c517; paper-result-6fd617ba744c55f823; paper-result-80618ad04474cfdfa4; paper-result-d0f2c61c9603a219fd; paper-result-2bf7f6f35cb278b8b3; paper-result-b4a0a133d3c57bbd78; paper-result-af213ccd00f688f0e8; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 4 SPOT-RNA, column 8: ArchiveII Precision; Table 1 (Tab1), row 5 MXfold2, column 8: ArchiveII Precision; Table 1 (Tab1), row 6 ContextFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 7 CONTRAfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 8 EternaFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 9 LinearFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 10 RNAfold, column 8: ArchiveII Precision; Table 1 (Tab1), row 11 SimFold, column 8: ArchiveII Precision; Table 1 (Tab1), row 12 RNAstructure, column 8: ArchiveII Precision; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab1-archiveii-recall; title: ArchiveII · Recall; protocol id: paper-protocol-e8a1aa302bb8df1efd; dataset id: paper-dataset-be2c18a91718ba4592; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-23d3090d9e3540349d; paper-result-b79992ef838378f5c1; paper-result-e038536d6f9b001984; paper-result-d82764605cdb73aad8; paper-result-57de4fbe015fbae501; paper-result-a8cf704b852f820e32; paper-result-5f273213a7f48d1b55; paper-result-8164922a733ea800eb; paper-result-ccd93245b92c3d3620; paper-result-cf786103471c989dd3; source ids: bpfold-2025; source locator: Sequence-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold), and non-ML methods (LinearFold, RNAfold, SimFold, and RNAstructure) on bpRNA-TS0 ( n  = 1305 RNAs) and ArchiveII ( n  = 3966 RNAs) datasets; Table 1 (Tab1), row 3 BPfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 4 SPOT-RNA, column 9: ArchiveII Recall; Table 1 (Tab1), row 5 MXfold2, column 9: ArchiveII Recall; Table 1 (Tab1), row 6 ContextFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 7 CONTRAfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 8 EternaFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 9 LinearFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 10 RNAfold, column 9: ArchiveII Recall; Table 1 (Tab1), row 11 SimFold, column 9: ArchiveII Recall; Table 1 (Tab1), row 12 RNAstructure, column 9: ArchiveII Recall; context: Sequence-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-inf; title: Rfam12.3–14.10 · INF; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: INF; unit: unitless; direction: higher; result ids: paper-result-bc33c532295af7b251; paper-result-d3521184aa90f4092f; paper-result-625df7ddcc5441ab69; paper-result-ae0e3455f6b89e6f70; paper-result-57fc7701f0c9da77d0; paper-result-26e74e5c77ce1570a9; paper-result-ad4f1a6205fecd1b6d; paper-result-d197148a19effcf018; paper-result-68b0000887cc4b5e80; paper-result-853e1b3f8354ef0290; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 4 SPOT-RNA, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 5 MXfold2, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 6 ContextFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 7 CONTRAfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 8 EternaFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 9 LinearFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 10 RNAfold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 11 SimFold, column 2: Rfam12.3–14.10 INF; Table 2 (Tab2), row 12 RNAstructure, column 2: Rfam12.3–14.10 INF; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-f1; title: Rfam12.3–14.10 · F1; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: F1; unit: unitless; direction: higher; result ids: paper-result-d8fb52a660fba363da; paper-result-3019f81982dc6332cf; paper-result-0ce94efc1ed30c3769; paper-result-a34fce1d750df98700; paper-result-ac79fb8c90b25f7318; paper-result-3db670da1582c96f89; paper-result-f60a9b4fba0bdd5bca; paper-result-5c3a3c43a76fcaeb84; paper-result-7f0004110bb610598b; paper-result-31c527dabf4e1f6958; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 4 SPOT-RNA, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 5 MXfold2, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 6 ContextFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 7 CONTRAfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 8 EternaFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 9 LinearFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 10 RNAfold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 11 SimFold, column 3: Rfam12.3–14.10 F1; Table 2 (Tab2), row 12 RNAstructure, column 3: Rfam12.3–14.10 F1; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-precision; title: Rfam12.3–14.10 · Precision; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-4c05190191ba52c1d1; paper-result-22774caf06553a0120; paper-result-03b61894f52b9f6a21; paper-result-39a55efc7440a14e65; paper-result-c859a2ad30d5982c35; paper-result-d49a44e7ee0390f25d; paper-result-6e6c7831c443afa6ed; paper-result-e59816ecb58e31617e; paper-result-b6a697b1154c255641; paper-result-f3fb35d7219cc3367e; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 4 SPOT-RNA, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 5 MXfold2, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 6 ContextFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 7 CONTRAfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 8 EternaFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 9 LinearFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 10 RNAfold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 11 SimFold, column 4: Rfam12.3–14.10 Precision; Table 2 (Tab2), row 12 RNAstructure, column 4: Rfam12.3–14.10 Precision; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-rfam12-3-14-10-recall; title: Rfam12.3–14.10 · Recall; protocol id: paper-protocol-4c3af10c18f615709d; dataset id: paper-dataset-816ebb930725137655; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-399712a182e4786639; paper-result-c824c3c83e5e451637; paper-result-a1f081e3b661ff4c25; paper-result-99b4cc2229fcdd0626; paper-result-0c3b54bf620bf11af3; paper-result-b94255fbaa7ff64d55; paper-result-453956286dc654a2fc; paper-result-30d6b97036164e9290; paper-result-c7d3e722ba9b016c03; paper-result-975ccfae7d5107a44a; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 4 SPOT-RNA, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 5 MXfold2, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 6 ContextFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 7 CONTRAfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 8 EternaFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 9 LinearFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 10 RNAfold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 11 SimFold, column 5: Rfam12.3–14.10 Recall; Table 2 (Tab2), row 12 RNAstructure, column 5: Rfam12.3–14.10 Recall; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-inf; title: PDB · INF; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: INF; unit: unitless; direction: higher; result ids: paper-result-97b54396c089187bac; paper-result-5465552e8e451ecd56; paper-result-e465e8b97a72acc635; paper-result-d1041275466a1cb1ae; paper-result-3d0a9108d41aebb9db; paper-result-3ddc4380f7d4e8cc34; paper-result-738dbc58785cabadb7; paper-result-c2cbc18894bd07f1a6; paper-result-155bc3cd1981f1e9fd; paper-result-cfbfd2a82ace58ed84; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 6: PDB INF; Table 2 (Tab2), row 4 SPOT-RNA, column 6: PDB INF; Table 2 (Tab2), row 5 MXfold2, column 6: PDB INF; Table 2 (Tab2), row 6 ContextFold, column 6: PDB INF; Table 2 (Tab2), row 7 CONTRAfold, column 6: PDB INF; Table 2 (Tab2), row 8 EternaFold, column 6: PDB INF; Table 2 (Tab2), row 9 LinearFold, column 6: PDB INF; Table 2 (Tab2), row 10 RNAfold, column 6: PDB INF; Table 2 (Tab2), row 11 SimFold, column 6: PDB INF; Table 2 (Tab2), row 12 RNAstructure, column 6: PDB INF; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-f1; title: PDB · F1; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: F1; unit: unitless; direction: higher; result ids: lit-011; paper-result-57c0ff7b77a652ab1c; paper-result-3d2877af386639e0ad; paper-result-4ae34e1cc310c60554; paper-result-b6a3c4b03b40732ef2; paper-result-96d2c93b67543eaa47; paper-result-9440f5e0b35b26980b; lit-012; paper-result-fda0f45ba9232f7233; paper-result-c35bfeb0f7fc67fda6; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 7: PDB F1; Table 2 (Tab2), row 4 SPOT-RNA, column 7: PDB F1; Table 2 (Tab2), row 5 MXfold2, column 7: PDB F1; Table 2 (Tab2), row 6 ContextFold, column 7: PDB F1; Table 2 (Tab2), row 7 CONTRAfold, column 7: PDB F1; Table 2 (Tab2), row 8 EternaFold, column 7: PDB F1; Table 2 (Tab2), row 9 LinearFold, column 7: PDB F1; Table 2 (Tab2), row 10 RNAfold, column 7: PDB F1; Table 2 (Tab2), row 11 SimFold, column 7: PDB F1; Table 2 (Tab2), row 12 RNAstructure, column 7: PDB F1; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-precision; title: PDB · Precision; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: Precision; unit: unitless; direction: higher; result ids: paper-result-8319fb26cf3f85d194; paper-result-eac4aa84532a86e39b; paper-result-b6a55e179b51c6398e; paper-result-5ae72ffe6dc5e67fcd; paper-result-d4877662e8f67af294; paper-result-49bafa3b1c623a5f8d; paper-result-c96dd6eb50a381f576; paper-result-2d080d038082cd24e2; paper-result-ddafb4472501414293; paper-result-c9d2c92f2b018f5062; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 8: PDB Precision; Table 2 (Tab2), row 4 SPOT-RNA, column 8: PDB Precision; Table 2 (Tab2), row 5 MXfold2, column 8: PDB Precision; Table 2 (Tab2), row 6 ContextFold, column 8: PDB Precision; Table 2 (Tab2), row 7 CONTRAfold, column 8: PDB Precision; Table 2 (Tab2), row 8 EternaFold, column 8: PDB Precision; Table 2 (Tab2), row 9 LinearFold, column 8: PDB Precision; Table 2 (Tab2), row 10 RNAfold, column 8: PDB Precision; Table 2 (Tab2), row 11 SimFold, column 8: PDB Precision; Table 2 (Tab2), row 12 RNAstructure, column 8: PDB Precision; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17; id: bpfold-2025-tab2-pdb-recall; title: PDB · Recall; protocol id: paper-protocol-b8acf180ccd3e67923; dataset id: reported-dataset-8317793f18b026; metric: Recall; unit: unitless; direction: higher; result ids: paper-result-5afb76a439dd9677b9; paper-result-3ad0144bc78eae6759; paper-result-01efc77bc3fe0c8593; paper-result-5fe58d35cc68e79078; paper-result-11126a2ff54dbf3afb; paper-result-a45e9b5b53f964bd93; paper-result-8828c8e20f56d3d354; paper-result-6f6f94f1d2e661baac; paper-result-a7667b03bef3a87b94; paper-result-c0cf50ee8c90573ad2; source ids: bpfold-2025; source locator: Family-wise evaluation of three DL methods (BPfold, SPOT-RNA, and MXfold2), three shallow learning methods (ContextFold, CONTRAfold, and EternaFold) and non-learning methods (LinearFold, RNAfold, SimFold, and RNAstructure) on Rfam12.3–14.10 ( n  = 10,791 RNAs) and PDB ( n  = 116 RNAs) datasets; Table 2 (Tab2), row 3 BPfold, column 9: PDB Recall; Table 2 (Tab2), row 4 SPOT-RNA, column 9: PDB Recall; Table 2 (Tab2), row 5 MXfold2, column 9: PDB Recall; Table 2 (Tab2), row 6 ContextFold, column 9: PDB Recall; Table 2 (Tab2), row 7 CONTRAfold, column 9: PDB Recall; Table 2 (Tab2), row 8 EternaFold, column 9: PDB Recall; Table 2 (Tab2), row 9 LinearFold, column 9: PDB Recall; Table 2 (Tab2), row 10 RNAfold, column 9: PDB Recall; Table 2 (Tab2), row 11 SimFold, column 9: PDB Recall; Table 2 (Tab2), row 12 RNAstructure, column 9: PDB Recall; context: Family-wise RNA secondary-structure evaluation; macro-average canonical base-pair metrics.; caveats: Within each dataset and metric only. Distinct training data, thermodynamic priors and learned methods are retained; dataset size is not a base-pair denominator. These are BPfold-author evaluations of external methods, not Rewire reproductions. Origins are labelled per method; appearance in one table does not constitute independent replication of every model.; review: method: automated_source_review; date: 2026-09-17
benchmark research
review date: 2026-09-17; status: complete_tables_extracted; primary sources: evidence-expansion-bpfold-2025-976218bd; inspected locators: Table 1; XML table Tab1; Table 2; XML table Tab2; searched queries: Deep generalizable prediction of RNA secondary structure via base pair motif energy 10.1038/s41467-025-60048-1; gaps: exact checkpoint hashes and per-method scored denominators: Table labels alone do not establish these fields; do not infer checkpoint or scored count from model name or dataset size.; claim scope: Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.
historical missing metadata
protocol version: not_reported_in_legacy_extract; split: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This source-scoped record identifies the biological prediction task and holds its paper context. Preserve the existing task identity; exact split, model adaptation and scoring remain in linked evaluations or separate protocol records.; source ids: bpfold-2025; source locator: Introduction; Methods: Datasets and evaluation; cached text lines 9, 44, 74–77; matching task comparison table/ablation captions; ambiguities: A paper- or suite-specific task may constrain some inputs or metrics; that alone does not make it interchangeable with a complete versioned protocol. No protocol equivalence is inferred.; Some legacy profile Entity type facts use the generic phrase computational evaluation protocol. That boilerplate is not sufficient to establish a single fixed protocol identity or to merge this task with another protocol record.
Related records

Suggest a correction