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K-neighbors classifier (log CP10k)

K-neighbors classifier uses the "k-nearest neighbours" approach, which is a popular machine learning algorithm for classification and regression tasks. The assumption underlying KNN in this context is that cells with similar gene expression profiles tend to belong to the same cell type. For each unlabelled cell, this method computes the $k$ labelled cells (in this case, 5) with the smallest distance in PCA space, and assigns that cell the most common cell type among its $k$ nearest neighbors.

24 evaluations · 24 metric rows

Overview

K-neighbors classifier uses the "k-nearest neighbours" approach, which is a popular machine learning algorithm for classification and regression tasks. The assumption underlying KNN in this context is that cells with similar gene expression profiles tend to belong to the same cell type. For each unlabelled cell, this method computes the $k$ labelled cells (in this case, 5) with the smallest distance in PCA space, and assigns that cell the most common cell type among its $k$ nearest neighbors.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

Release 2026-09-17-134cd1815de8 · 24 evaluations · 24 metric rows. Different protocols are not a single leaderboard. Where several source tables report the same metric, the published comparisons above offer a pooled view that names what it does not hold constant.

Results grouped by the exact reported evaluation
Metric and findingCoverage and uncertaintyEvidence
K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-BATCH-ACCURACY: Label projection on CeNGEN (split by batch), Accuracy

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test by experimental batch. Dimensions: 100955 cells, 22469 genes. 169 cell types (avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8124625524266027 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-BATCH-F1: Label projection on CeNGEN (split by batch), F1 score

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test by experimental batch. Dimensions: 100955 cells, 22469 genes. 169 cell types (avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.831091398368635 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-BATCH-F1-MACRO: Label projection on CeNGEN (split by batch), Macro F1 score

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test by experimental batch. Dimensions: 100955 cells, 22469 genes. 169 cell types (avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.39834484361073036 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-RANDOM-ACCURACY: Label projection on CeNGEN (random split), Accuracy

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test randomly. Dimensions: 100955 cells, 22469 genes. 169 cell types avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8492439964423362 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_random), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-RANDOM-F1: Label projection on CeNGEN (random split), F1 score

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test randomly. Dimensions: 100955 cells, 22469 genes. 169 cell types avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8517360245741384 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection CENGEN-RANDOM-F1-MACRO: Label projection on CeNGEN (random split), Macro F1 score

100k FACS-isolated C. elegans neurons from 17 experiments sequenced on 10x Genomics. Split into train/test randomly. Dimensions: 100955 cells, 22469 genes. 169 cell types avg. 597±800 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.7672490394127152 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(cengen_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-BATCH-ACCURACY: Label projection on Pancreas (by batch), Accuracy

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test by experimental batch. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.874492832025967 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-BATCH-F1: Label projection on Pancreas (by batch), F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test by experimental batch. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8731145520258626 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-BATCH-F1-MACRO: Label projection on Pancreas (by batch), Macro F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test by experimental batch. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8089500380663799 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_batch), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-ACCURACY: Label projection on Pancreas (random split), Accuracy

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.9650455927051672 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-F1: Label projection on Pancreas (random split), F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.964346201217482 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-F1-MACRO: Label projection on Pancreas (random split), Macro F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8962212379632082 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-LABEL-NOISE-ACCURACY: Label projection on Pancreas (random split with label noise), Accuracy

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly with 20% label noise. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.9463790446841295 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random_label_noise), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-LABEL-NOISE-F1: Label projection on Pancreas (random split with label noise), F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly with 20% label noise. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.9460810866713062 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random_label_noise), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection PANCREAS-RANDOM-LABEL-NOISE-F1-MACRO: Label projection on Pancreas (random split with label noise), Macro F1 score

Human pancreatic islet scRNA-seq data from 6 datasets across technologies (CEL-seq, CEL-seq2, Smart-seq2, inDrop, Fluidigm C1, and SMARTER-seq). Split into train/test randomly with 20% label noise. Dimensions: 16382 cells, 18771 genes. 14 cell types (avg. 1170±1703 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8361237623993133 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(pancreas_random_label_noise), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection TABULA-MURIS-SENIS-LUNG-RANDOM-ACCURACY: Label projection on Tabula Muris Senis Lung (random split), Accuracy

All lung cells from Tabula Muris Senis, a 500k cell-atlas from 18 organs and tissues across the mouse lifespan. Split into train/test randomly. Dimensions: 24540 cells, 17985 genes. 39 cell types (avg. 629±999 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8611835506519558 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(tabula_muris_senis_lung_random), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection TABULA-MURIS-SENIS-LUNG-RANDOM-F1: Label projection on Tabula Muris Senis Lung (random split), F1 score

All lung cells from Tabula Muris Senis, a 500k cell-atlas from 18 organs and tissues across the mouse lifespan. Split into train/test randomly. Dimensions: 24540 cells, 17985 genes. 39 cell types (avg. 629±999 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8585497668879454 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(tabula_muris_senis_lung_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection TABULA-MURIS-SENIS-LUNG-RANDOM-F1-MACRO: Label projection on Tabula Muris Senis Lung (random split), Macro F1 score

All lung cells from Tabula Muris Senis, a 500k cell-atlas from 18 organs and tissues across the mouse lifespan. Split into train/test randomly. Dimensions: 24540 cells, 17985 genes. 39 cell types (avg. 629±999 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8714241831337218 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(tabula_muris_senis_lung_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-LABS-ACCURACY: Label projection on Zebrafish (by laboratory), Accuracy

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test by laboratory. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.12981704943557804 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_labs), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-LABS-F1: Label projection on Zebrafish (by laboratory), F1 score

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test by laboratory. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.14229308051699885 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_labs), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-LABS-F1-MACRO: Label projection on Zebrafish (by laboratory), Macro F1 score

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test by laboratory. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.16437714442609613 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_labs), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-RANDOM-ACCURACY: Label projection on Zebrafish (random split), Accuracy

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test randomly. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8060711523588554 accuracy

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_random), method(k_neighbors_classifier), paramset(log CP10k), metric(accuracy)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-RANDOM-F1: Label projection on Zebrafish (random split), F1 score

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test randomly. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.8014734891499417 f1

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1)

Source checking is not independent reproduction.

K-neighbors classifier (log CP10k) on Open Problems label projection ZEBRAFISH-RANDOM-F1-MACRO: Label projection on Zebrafish (random split), Macro F1 score

90k cells from zebrafish embryos throughout the first day of development, with and without a knockout of chordin, an important developmental gene. Split into train/test randomly. Dimensions: 26022 cells, 25258 genes. 24 cell types (avg. 1084±1156 cells per cell type).

Author-reported evaluation · Evaluation metadata: source checked

0.6240963193194412 f1-macro

Unit: fraction · Direction: higher

Uncertainty: Not reported

Scored: Not reported · Eligible: Not reported

source checkedopenproblems-label primary benchmark evidence · results, dataset(zebrafish_random), method(k_neighbors_classifier), paramset(log CP10k), metric(f1_macro)

Source checking is not independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-17-134cd1815de8
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Sources and history

Release 2026-09-17-134cd1815de8 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: open-problems-method-k-neighbors-classifier-log-cp10k

areas
cells-tissues
source locator
results, method(k_neighbors_classifier), paramset(log CP10k)
missing metadata
checkpoint revision: unreported; parameters: unextracted
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